Neural Regen Res文献导读：端粒酶与神经元的不寻常

作者：张馨予

　　Neural Regeneration Research

　　November 2022

　　Volume 17 Number 11

　　综述

　　Neuroprotection and neuroregeneration: roles for the white matter

　　神经保护和神经再生：白质的作用

　　Vito Antonio Baldassarro, Agnese Stanzani, Luciana Giardino, Laura Calzà, Luca Lorenzini

　　Telomerase and neurons: an unusual relationship

　　端粒酶与神经元：一种不寻常的关系

　　Gabriele Saretzki

　　An atypical ubiquitin ligase at the heart of neural development and programmed axon degeneration

　　神经发育和程序性轴突退化核心的非典型泛素连接酶

　　Satpal Virdee

　　Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions

　　生理和病理条件下脑中 SOX 转录因子和 microRNA 的相互作用

　　Milena Stevanovic, Danijela Stanisavljevic Ninkovic, Marija Mojsin, Danijela Drakulic, Marija Schwirtlich

　　The endogenous progenitor response following traumatic brain injury: a target for cell therapy paradigms

　　创伤性脑损伤后的内源性祖细胞反应：细胞治疗范例的目标

　　Anna Badner, Brian J. Cummings

　　Purinergic signaling systems across comparative models of spinal cord injury

　　跨脊髓损伤比较模型的嘌呤能信号系统

　　Eva E. Stefanova, Angela L. Scott

　　Advancements in our understanding of circular and long non-coding RNAs in spinal cord injury

　　脊髓损伤中的环状和长链非编码RNA

　　Yan Zhang, Ho Jun Yun, Yu Ji, Eric Cosky, Wen-Xiu Zhang, Wei Han, Yu-Chuan Ding

　　Emerging blood exosome-based biomarkers for preclinical and clinical Alzheimer’s disease: a meta-analysis and systematic review

　　用于临床前和临床阿尔茨海默病的新兴外泌体的血液生物标记物：荟萃分析和系统评价

　　Wei-Lin Liu, Hua-Wei Lin, Miao-Ran Lin, Yan Yu, Huan-Huan Liu, Ya-Ling Dai, Le-Wen Chen, Wei-Wei Jia, Xiao-Jun He, Xiao-Ling Li, Jing-Fang Zhu, Xie-Hua Xue, Jing Tao, Li-Dian Chen

　　The relationship between amyloidbeta and brain capillary endothelial cells in Alzheimer’s disease

　　阿尔茨海默病中β淀粉样蛋白与脑毛细血管内皮细胞的关系

　　Yan-Li Zhang, Juan Wang, Zhi-Na Zhang, Qiang Su, Jun-Hong Guo

　　Neuroinflammation as a mechanism linking hypertension with the increased risk of Alzheimer's disease

　　神经炎症作为将高血压与阿尔茨海默病风险增加联系起来的机制

　　Ekta Bajwa, Andis Klegeris

　　Lipopolysaccharide mouse models for Parkinson’s research: a critical appraisal

　　于帕金森研究的脂多糖小鼠模型：一项重要的评估

　　Isaac Deng, Larisa Bobrovskaya

　　The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline

　　肠道菌群改变对年龄相关性神经炎症和认知能力下降的影响

　　Amsha S. Alsegiani, Zahoor A. Shah

　　Cerebellar pathology in motor neuron disease: neuroplasticity and neurodegeneration

　　运动神经元病的小脑病理：神经可塑性和神经退行性

　　Rangariroyashe H. Chipika, Grainne Mulkerrin, Pierre-François Pradat, Aizuri Murad, Fabrice Ango, Cédric Raoul, Peter Bede

　　MicroRNAs as biomarkers in glaucoma and potential therapeutic targets

　　作为青光眼生物标志物的MicroRNAs和潜在的治疗目标

　　Bridget Martinez, Philip V. Peplow

　　The uPA/uPAR system in astrocytic wound healing

　　星形胶质细胞伤口愈合中的 uPA/uPAR 系统

　　Manuel Yepes

　　观点

　　Non-canonical role of the ATR pathway in axon regeneration as a mechanosensitive brake

　　ATR 通路在轴突再生中作为机械敏感制动器的非典型作用

　　Feng Li, Yuanquan Song

　　Beyond vertebrates: the amphioxus as a relevant model system to explore the formation, organization, and regeneration of neuromuscular synapses

　　脊椎动物之外：文昌鱼作为探索神经肌肉突触形成、组织和再生的相关模型系统

　　Esperanza Martínez, Sylvain Marcellini, Juan Pablo Henríquez

　　Engineering cerebral folding in brain organoids

　　脑类器官中的工程脑折叠

　　Glen Scott, Yu Huang

　　Utilizing multiphoton imaging and integrative clearing to reveal sex differences in neuroimmune interactions after nerve injury

　　利用多光子成像和综合清除揭示神经损伤后神经免疫相互作用的性别差异

　　Zachary W. Castillo, Michael D. Burton

　　Perspective on automated in vivo drug screening using the chodl mutant zebrafish line

　　使用 chodl 突变斑马鱼品系进行自动体内药物筛选的观点

　　Ana-Maria Oprişoreanu

　　Are ATXN2 variants modifying our understanding about neural pathogenesis, phenotypes, and diagnostic?

　　ATXN2 变体是否改变了我们对神经发病机制、表型和诊断的理解？

　　Jose Miguel Laffita-Mesa, Martin Paucar, Per Svenningsson

　　TDP-35, a truncated fragment of TDP-43, induces dose-dependent toxicity and apoptosis in flies

　　TDP-35 是 TDP-43 的截短片段，可在果蝇中诱导剂量依赖性毒性和细胞凋亡

　　Deepak Chhangani, Diego E. Rincon-Limas

　　Verapamil, a possible repurposed therapeutic candidate for stroke under hyperglycemia

　　维拉帕米，一种可能重新用于治疗高血糖卒中的候选药物

　　Saifudeen Ismael, Tauheed Ishrat

　　Targeting O-GlcNAcylation in ischemic stroke

　　靶向缺血性卒中的 O-GlcNAcylation

　　Xuan Li, Wei Yang

　　The left-right side-specific endocrine signaling: implications for neurological deficits in stroke and neurodevelopmental disorders

　　左右侧特异性内分泌信号：对脑卒中和神经发育障碍中的神经系统缺陷的影响

　　Georgy Bakalkin, Nikolay Lukoyanov, Igor Lavrov, Mengliang Zhang

　　Transcription factors promote neural regeneration after spinal cord injury

　　转录因子促进脊髓损伤后神经再生

　　Zachary Finkel, Li Cai

　　Can foods influence the onset and progress of neurodegenerative diseases?

　　食物会影响神经退行性疾病的发作和进展吗？

　　Luca Piemontese, Leonardo Brunetti, Rosalba Leuci

　　Modeling Alzheimer’s disease: considerations for a better translational and replicable mouse model

　　阿尔茨海默病建模：对更好的转化和可复制的考虑鼠模型"

　　Joshua D. Cho, Mu Yang, Ismael Santa-Maria

　　Finding effective combinations of compounds to prevent Alzheimer's disease

　　寻找有效的化合物组合来预防阿尔茨海默病

　　Sudip Dhakal, Ian Macreadie*

　　Chemically oligomerizable TAR-DNA binding protein 43: a novel chemogenetic tool for studying the pathophysiology of amyotrophic lateral sclerosis

　　化学寡聚 TAR-DNA 结合蛋白 43：一种用于研究肌萎缩侧索硬化病理生理学的新型化学遗传工具

　　Kohsuke Kanekura, Yoshiaki Yamanaka, Tamami Miyagi, Masahiko Kuroda

　　研究原著

　　脑损伤与神经再生

　　ADAM10 facilitates rapid neural stem cell cycling and proper positioning within the subventricular zone niche via JAMC/RAP1Gap signaling

　　ADAM10通过JAMC/RAP1Gap信号通路促进神经干细胞快速循环并在脑室下区干细胞龛正确定位

　　Nadia McMillan, Gregory W. Kirschen, Sanket Desai, Emma Xia, Stella E. Tsirka, Adan Aguirre

　　Effects of progesterone on T-type-Ca2+-channel expression in Purkinje cells

　　孕酮对浦肯野细胞中T型Ca2+通道表达的影响

　　Annika Eickhoff, Jonas Tjaden, Sarah Stahlke, Matthias Vorgerd, Verena Theis, Veronika Matschke, Carsten Theiss

　　Silencing miRNA-324-3p protects against cerebral ischemic injury via regulation of the GATA2/A1R axis

　　沉默miRNA-324-3p对脑缺血的神经保护作用

　　An-Qi Zhang, Lu Wang, Yi-Xiu Wang, Shan-Shan Hong, Yu-Shan Zhong, Ru-Yi Yu, Xin-Lu Wu, Bing-Bing Zhou, Qi-Min Yu, Hai-Feng Fu, Shuang-Dong Chen, Yun-Chang Mo, Qin-Xue Dai, Jun-Lu Wang

　　An enriched environment reduces hippocampal inflammatory response and improves cognitive function in a mouse model of stroke

　　丰富环境减轻脑卒中海马炎症反应及改善认知功能

　　Hong-Yu Zhou, Ya-Ping Huai, Xing Jin, Ping Yan, Xiao-Jia Tang, Jun-Ya Wang, Nan Shi, Meng Niu, Zhao-Xiang Meng, Xin Wang

　　Obstructive sleep apnea aggravates neuroinflammation and pyroptosis in early brain injury following subarachnoid hemorrhage via ASC/HIF-1α pathway

　　睡眠呼吸暂停加重蛛网膜下腔出血后早期脑损伤中的神经炎症和细胞焦亡

　　Jun Xu, Qian Li, Chen-Yu Xu, Shan Mao, Jia-Jia Jin, Wei Gu, Ying Shi, Chun-Fang Zou, Liang Ye

　　A three-dimensional matrix system containing melatonin and neural stem cells repairs damage from traumatic brain injury in rats

　　基质胶、褪黑素与神经干细胞三维移植体系修复创伤性脑损伤

　　Xuan-Yu Fang, Da-Wei Zhao, Chao Zhang, Hong-Fei Ge, Xu-Yang Zhang, Feng-Chun Zhao, Yi-Bin Jiang, Hua Feng, Rong Hu

　　Human umbilical cord-derived mesenchymal stem cells promote repair of neonatal brain injury caused by hypoxia/ischemia in rats

　　人脐带源间充质干细胞促进缺氧缺血性幼鼠脑损伤的修复

　　Yang Jiao, Yue-Tong Sun, Nai-Fei Chen, Li-Na Zhou, Xin Guan, Jia-Yi Wang, Wen-Juan Wei, Chao Han, Xiao-Lei Jiang, Ya-Chen Wang, Wei Zou, Jing Liu

　　In vivo neuronal and astrocytic activation in somatosensory cortex by acupuncture stimuli

　　针刺可激活大脑躯体感觉皮质中的神经元和星形胶质细胞

　　Xiao-Yue Chang, Kai Chen, Tong Cheng, Pui To Lai, Li Zhang, Kwok-Fai So, Edward S. Yang

　　Different frequencies of repetitive transcranial magnetic stimulation combined with local injection of botulinum toxin type A for post-stroke lower limb spasticity: study protocol for a prospective, single-center, nonrandomized, controlled clinical trial

　　不同频率重复经颅磁刺激联合A型肉毒毒素局部注射治疗脑卒中后下肢肌肉痉挛的最佳方案：前瞻性、单中心、非随机、对照临床试验方案

　　Yang Shao, Yang Yang, Yong-Xin Sun, Ai-Hua Xu

　　脊髓损伤与神经再生

　　Evolution of the ErbB gene family and analysis of regulators of Egfr expression during development of the rat spinal cord

　　大鼠脊髓发育过程中Egfr的进化与调控网络

　　Yu Zhang, Tao Zhang, Lian Xu, Ye Zhu, Li-Li Zhao, Xiao-Di Li, Wei-Wei Yang, Jing Chen, Miao Gu, Xiao-Song Gu, Jian Yang

　　Effects of paired associative magnetic stimulation between nerve root and cortex on motor function of lower limbs after spinal cord injury: study protocol for a randomized controlled trial

　　神经根和皮质之间的配对相关磁刺激对脊髓损伤后的下肢运动功能的影响：一项随机对照试验方案

　　Ting-Ting Sun, Guang-Yue Zhu, Ya Zheng, Ye-Ran Mao, Qi-Long Hu, Gong-Ming Song, Rong Xu, Qi Yang, Dan Zhao, Xu-Yun Hua, Dong-Sheng Xu

　　神经退行性疾病与神经再生

　　Genetic dissection of glutathione S-transferase omega-1: identification of novel downstream targets and Alzheimer’s disease pathways

　　谷胱甘肽 S-转移酶 omega-1 的遗传解剖：新下游靶点和阿尔茨海默病通路鉴定

　　Yue Jia, Meng-Die Gao, Yun-Fang Liu, Lu Lu, Gang Chen, Ying Chen

　　NOVA1 promotes SMN2 exon 7 splicing by binding the UCAC motif and increases SMN protein expression

　　NOVA1通过结合UCAC基序促进SMN2外显子7剪接并增加SMN蛋白表达

　　Li-Li Du, Jun-Jie Sun, Zhi-Heng Chen, Yi-Xiang Shao, Liu-Cheng Wu

　　周围损伤与神经再生

　　Polydopamine-modified chitin conduits with sustained release of bioactive peptides enhance peripheral nerve regeneration in rats

　　加载生长因子模拟肽的聚多巴胺涂层甲壳质导管可有效增强周围神经再生

　　Ci Li, Song-Yang Liu, Li-Ping Zhou, Tian-Tian Min, Meng Zhang, Wei Pi, Yong-Qiang Wen, Pei-Xun Zhang

　　影像图片

　　Delayed activation of leg somatotopic fibers of an injured corticospinal tract in a patient with cerebral infarction

　　脑梗死患者损伤皮质脊髓束的腿部体感纤维的延迟激活

　　Min Jye Cho, Sung Ho Jang